�Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components. The importance of MMPs in tumour development and invasion as well as other diseases is well known.
AnaSpec has introduced the SensoLyteTM 570 Generic MMP Assay Kit, oblation the industry's highest emission wavelength for MMP sensing. The higher emission wavelength allows the SensoLyteTM 570 Generic MMP Assay Kit to offer greater sensibility in detecting enzyme activities with minimum interference from the autofluorescence of cellular phone components and test compounds. This kit is idealistic for detective work generic MMP activity in biological samples or for high throughput screening of MMP inducers and inhibitors using purified MMPs.
The SensoLyte� 570 Generic MMP Assay Kit is optimized to detect the body process of a variety of MMPs, including MMP-1, 2, 7, 8, 9, 10, 13, and 14 (Fig.1). This kit uses a FRET peptide substrate tagged with 5-TAMRA (fluorophore) and QXL� 570 (quencher) for continuous measure of enzyme activities. In an intact FRET peptide, the fluorescence of 5-TAMRA is squelched by QXL� 570. Upon the cleavage of the FRET peptide by MMPs, the fluorescence of 5-TAMRA is healed, and john be incessantly monitored at excitation/emission = 540 nm/575 nm. The assays are performed in a convenient 96-well arrange.
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AnaSpec is a ahead provider of integrated proteomics solutions to the world's largest biotech, pharmaceutical, and academic research institutions. With a vision for instauration through synergism, AnaSpec focuses on leash core technologies: peptides, detection reagents (including dyes, assay kits, and antibodies) and combinatorial chemistry.
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